MF 8 - Postdoc (Djinovic Carugo)

Protein Characterization Facility 

Duration of contract: 3 years 
Planned starting date: ASAP 
Place of work: University of Vienna

Main supervisor: Kristina Djinovic Carugo (CV
Supervision team: Leonid Sazanov, Ruth Birner-Grünberger, Thomas Rattei


This position has been filled.


Project description:

CoE microbiome project will generate a realm of core molecular data ranging from from genomes, proteomes, metabolomes, transcriptomes to microbiomes. We anticipate a high fraction of "dark matter" in terms of function: that is, with elusive or entirely unidentified function.  
In order to gain mechanistic understanding of processes in which selected representative proteins or protein complexes are involved, we will biochemically and biophysically characterise them and genedate structural models using integrative structural biology approach. The topics in which Djinovic lab is currently involved regard enzymes from complete ammonium oxidation patway, as well as selected metabolic enzymes from Comammox bacteria, in particular N. inopinata. Close collaboration with the workpackage focused on Chemical Perturbations and Microbiome Functioning, and particular on studies on Impact of Drugs on Microbiomes in Humans and Wastewater Treatment is planned. In vitro and structural studies of key enzymes will be carried out to assess substrate selectivity, pharmacological and biotransformation product inhibition, and potential for biotechnological optimisation.



Method facilities

Supervisor CV (351.82 KB)